Job Description

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we are pioneering new frontiers by identifying and treating patients earlier, working towards the aim of eliminating cancer as a cause of death. Come and join our AZ team where you will play a pivotal role in this exciting period of development!! Join our Particle and Process Engineering Team in ECD based in Macclesfield UK as a Scientist or Senior Scientist. We are looking for an enthusiastic, motivated and highly capable individual who can work closely with cross functional teams including chemists and many other scientists within the drug product units to contribute to Pharmaceutical Science projects. You will be involved in designing and implementing new final active pharmaceutical ingredient (API) processes with a focus on delivery quality API physical attributes, form and particle to meet clinical timelines and demands. You may also have the opportunity to plan and drive improvement projects, use new technologies or modify our ways of working within AstraZeneca or externally with our Contract Development and Manufacturing Organisations (CDMOs). Key Responsibilities:Provide crystallisation expertise in process development, process scale-up and manufacturability for drug substance and intermediates as an integral part of route development.Drive the Drug Substance control strategy, ensuring processes are fully understood and will robustly deliver consistent drug substance quality and align with Drug Product control strategy.Work collaboratively with colleagues in Drug Product Development to identify and define the required solid form and particle properties for downstream processing.Contribute to complex projects focusing on sustainable process development and manufacture of drug substances and provide the link through to Drug Product.Act as a scientific expert to deliver our science and technology strategy and other improvement activities both internal and external to the ECD department.