Job Description
Neuroscience team at Astrazeneca With a rich heritage and an R&D focus on specific aspects of neurodegenerative diseases, analgesia and psychiatry, AstraZeneca continues to push the boundaries of science in neuroscience in collaboration with other innovative partners across industry and academia. Join a small, agile business unit, which runs semi autonomously within AstraZeneca and has a biotech culture, which is continuing to evolve and grow with new products and talent joining year on year! What you’ll do You will contribute clinical insights and disease understanding to the selection and evaluation of targets. An understanding of translational approaches to clinical trial design and regulatory process, proof-of-concept studies, and identification and implementation of biomarkers is a pre-requisite. You will help craft, implement and analyze translational biomarker studies to support clinical development, with an emphasis on proof of mechanism (PoM) and identification of patients likely to respond to the agent under development.
Responsibilities + Skills
Solid understanding of biologic and small molecule therapeutics. Experience with other modalities e.g. PROTACs, siRNA, gene editing would be desirable.Familiarity with predictive biomarkers and personalized medicine approaches
Education
Neuroscience training and experience in academia or industry, particularly in chronic pain or neurodegenerationHands-on experience in development of in vitro and in vivo assays for research and clinical use, with the aim of assessing biomarkers for PoM and patient selection.
Experience
